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GPCR

NameMu-type opioid receptor
SpeciesMacaca mulatta (Rhesus macaque)
GeneOPRM1
SynonymM-OR-1
MOR-1
DiseaseN/A for non-human GPCRs
Length400
Amino acid sequenceMDSSAVPTNASNCTDALAHSSCSPARSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALVTSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMSTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIICWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDEDFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProtQ9MYW9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5799
IUPHARN/A
DrugBankN/A

Ligand

NameEtonitazene
Molecular formulaC22H28N4O3
IUPAC name2-[2-[(4-ethoxyphenyl)methyl]-5-nitrobenzimidazol-1-yl]-N,N-diethylethanamine
Molecular weight396.491
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.3
SynonymsEtonitazine
Etonitazinum
Ciba 20-684BA
ARC 1G2
Etobedolum
[ Show all ]
Inchi KeyPXDBZSCGSQSKST-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3
PubChem CID13493
ChEMBLCHEMBL312040
IUPHAR1624
BindingDB50013847
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.01 nMPMID18403056BindingDB,ChEMBL
Ki0.02 nMPMID18403056BindingDB,ChEMBL

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