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GPCR

NameD(2) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD2
Synonymdopamine receptor 2
Dopamine D2 receptor
D2R
D2A and D2B
D2(415) and D2(444)
[ Show all ]
DiseaseSubstance dependence
Major depressive disorder
Maintain blood pressure in hypotensive states
Insomnia
Inflammatory disease
[ Show all ]
Length443
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP14416
Protein Data Bank6cm4, 6c38
GPCR-HGmod modelP14416
3D structure modelThis structure is from PDB ID 6cm4.
BioLiPBL0408379, BL0403379
Therapeutic Target DatabaseT67162
ChEMBLCHEMBL217
IUPHAR215
DrugBankBE0000756

Ligand

Name7-OH-DPAT
Molecular formulaC16H25NO
IUPAC name7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
Molecular weight247.382
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.1
SynonymsGTPL950
NCGC00015494-06
(+/-)-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-2-ol
7-Hydroxy-N,N-di-n-propyl-2-aminotetralin
AKOS015913437
[ Show all ]
Inchi KeyBLYMJBIZMIGWFK-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H25NO/c1-3-9-17(10-4-2)15-7-5-13-6-8-16(18)12-14(13)11-15/h6,8,12,15,18H,3-5,7,9-11H2,1-2H3
PubChem CID1219
ChEMBLCHEMBL285755
IUPHAR3296, 950
BindingDB50020222
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5039.8 nMPMID18410082BindingDB,ChEMBL
Emax61.4 %PMID18410082ChEMBL
Ki2.27 nMPMID27035329ChEMBL
Ki2.3 nMPMID27035329BindingDB
Ki2.7 nMPMID7756621PDSP
Ki25.1189 - 2511.89 nMPMID8301582, PMID7907989, PMID7576010IUPHAR
Ki60.0 nMPMID8301582PDSP,BindingDB
Ki89.0 nMPMID9067310PDSP,BindingDB
Ki103.0 nMPMID7756621PDSP
Ki142.0 nMPMID8230102, PMID7990123BindingDB,ChEMBL
Ki143.0 nMPMID27035329BindingDB,ChEMBL
Ki158.48 nMPMID10611634PDSP,BindingDB
Ki202.0 nMPMID20146482ChEMBL
Ki1430.0 nMPMID23018094BindingDB
Ki1780.0 nMPMID9067310PDSP,BindingDB

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