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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	CHEMBL2179687
Molecular formula	C27H34N4O5
IUPAC name	1-methyl-N-[[1-(4-phenylbutyl)piperidin-4-yl]methyl]indazole-3-carboxamide;oxalic acid
Molecular weight	494.592
Hydrogen bond acceptor	7
Hydrogen bond donor	3
XlogP	None
Synonyms	N/A
Inchi Key	BMBHQHFPEKQDOU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C25H32N4O.C2H2O4/c1-28-23-13-6-5-12-22(23)24(27-28)25(30)26-19-21-14-17-29(18-15-21)16-8-7-11-20-9-3-2-4-10-20;3-1(4)2(5)6/h2-6,9-10,12-13,21H,7-8,11,14-19H2,1H3,(H,26,30);(H,3,4)(H,5,6)
PubChem CID	71457296
ChEMBL	CHEMBL2179687
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	22.0 %	PMID23043420	ChEMBL
Inhibition	64.0 %	PMID23043420	ChEMBL
Inhibition	101.0 %	PMID23043420	ChEMBL

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