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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesRattus norvegicus (Rat)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length488
Amino acid sequenceMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP43114
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4086
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL2036321
Molecular formulaC28H30N2O4S2
IUPAC name2-[2-[(2R)-2-[(E,3S)-4-[3-(3,4-dimethylphenyl)phenyl]-3-hydroxybut-1-enyl]-5-oxopyrrolidin-1-yl]ethylsulfanyl]-1,3-thiazole-4-carboxylic acid
Molecular weight522.678
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP5.2
SynonymsBDBM50385141
SCHEMBL14270373
Inchi KeyQBUJKNBDVBZVJH-IEZNSWIASA-N
Inchi IDInChI=1S/C28H30N2O4S2/c1-18-6-7-22(14-19(18)2)21-5-3-4-20(15-21)16-24(31)10-8-23-9-11-26(32)30(23)12-13-35-28-29-25(17-36-28)27(33)34/h3-8,10,14-15,17,23-24,31H,9,11-13,16H2,1-2H3,(H,33,34)/b10-8+/t23-,24+/m0/s1
PubChem CID10481859
ChEMBLCHEMBL2036321
IUPHARN/A
BindingDB50385141
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5021.0 nMPMID22546206BindingDB,ChEMBL

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