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GPCR

NameP2Y purinoceptor 2
SpeciesHomo sapiens (Human)
GeneP2RY2
SynonymPurinergic receptor
purinergic receptor P2Y
P2Y2 receptor
P2Y2
P2Y purinoceptor 2
[ Show all ]
DiseaseDry eye disease
Constipation
Cystic fibrosis
Lung cancer
Length377
Amino acid sequenceMAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL
UniProtP41231
Protein Data BankN/A
GPCR-HGmod modelP41231
3D structure modelThis predicted structure model is from GPCR-EXP P41231.
BioLiPN/A
Therapeutic Target DatabaseT93515
ChEMBLCHEMBL4398
IUPHAR324
DrugBankBE0002401

Ligand

NameCHEMBL1957445
Molecular formulaC18H19N2O8PS
IUPAC name2-[(2R,3S,4R,5R)-5-[5-(1-benzothiophen-2-yl)-2,4-dioxopyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl]ethylphosphonic acid
Molecular weight454.39
Hydrogen bond acceptor9
Hydrogen bond donor5
XlogP-1.0
SynonymsBDBM50366149
Inchi KeyBMSFTRGDDXQGKF-BNGXUDDSSA-N
Inchi IDInChI=1S/C18H19N2O8PS/c21-14-11(5-6-29(25,26)27)28-17(15(14)22)20-8-10(16(23)19-18(20)24)13-7-9-3-1-2-4-12(9)30-13/h1-4,7-8,11,14-15,17,21-22H,5-6H2,(H,19,23,24)(H2,25,26,27)/t11-,14-,15-,17-/m1/s1
PubChem CID57400088
ChEMBLCHEMBL1957445
IUPHARN/A
BindingDB50366149
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<20000.0 nMPMID22386981BindingDB,ChEMBL
Emax45.0 %PMID22386981ChEMBL

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