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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1998041
Molecular formulaC21H14BrFN2O
IUPAC name5-bromo-4-(3-fluorophenyl)-2-(naphthalen-1-ylmethyl)pyridazin-3-one
Molecular weight409.258
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.9
SynonymsSR-02000001653
SR-02000001653-1
Inchi KeyBNFJKQUMVJNVGZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H14BrFN2O/c22-19-12-24-25(21(26)20(19)15-7-4-9-17(23)11-15)13-16-8-3-6-14-5-1-2-10-18(14)16/h1-12H,13H2
PubChem CID53364419
ChEMBLCHEMBL1998041
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50533.0 nMPubChem BioAssay data setChEMBL

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