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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL78339
Molecular formula	C18H28FN3O2
IUPAC name	1-(2-fluoroethyl)-3-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]urea
Molecular weight	337.439
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.3
Synonyms	BDBM50406659 1-[3-[3-(Piperidinomethyl)phenoxy]propyl]-3-(2-fluoroethyl)urea
Inchi Key	BNFNSTGIBNGTGC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H28FN3O2/c19-8-10-21-18(23)20-9-5-13-24-17-7-4-6-16(14-17)15-22-11-2-1-3-12-22/h4,6-7,14H,1-3,5,8-13,15H2,(H2,20,21,23)
PubChem CID	14994252
ChEMBL	CHEMBL78339
IUPHAR	N/A
BindingDB	50406659
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	85.11 nM	PMID1352351	BindingDB,ChEMBL

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