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GPCR

NameProbable G-protein coupled receptor 142
SpeciesMus musculus (Mouse)
GeneGpr142
SynonymG-protein coupled receptor PGR2
GPR142
KIF19
AXOR103
DiseaseN/A for non-human GPCRs
Length365
Amino acid sequenceMHLNSNPNSYICDAYQHADLLWSLSPHVLTKAVQPQVTLLPTVNGSNPRYDGVDGHWPESPERSPCVAGIIPVIYYSVLLSLGLPVALARLAARTRKPSYHYLLALTASDIVTQVIIVFVGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAVLFTVDRYNALCRPLRHRATSSPGRTHRAIAAVIGVTLLTGIPFYWWLDVWRDADPPSTMDKLLKWAHCLIVYFIPCNVFLVTNSAIILRLRKRGQRGLRPLVSKSTAILLGVTSLFALLWAPRIIVMLYHLYVAPVHRDWRVHLALDIANMLAMLNTEVNFGLYCFISKTFRATVRQVICDVHMACALKSQPKQTVVELMLKSVGTEL
UniProtQ7TQN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2069162
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2164850
Molecular formulaC27H25N5O2
IUPAC name(2S)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenyl-2-[(1-pyridin-2-ylcyclopropyl)amino]propanamide
Molecular weight451.53
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP2.1
Synonyms(S)-N-(2-Oxo-5-(pyridin-4-yl)-1,2-dihydropyridin-3-yl)-3-phenyl-2-(1-(pyridin-2-yl)cyclopropylamino)propanamide
BDBM50395776
QQQMLGGCBKAPKW-QHCPKHFHSA-N
SCHEMBL2684482
Inchi KeyQQQMLGGCBKAPKW-QHCPKHFHSA-N
Inchi IDInChI=1S/C27H25N5O2/c33-25-22(17-21(18-30-25)20-9-14-28-15-10-20)31-26(34)23(16-19-6-2-1-3-7-19)32-27(11-12-27)24-8-4-5-13-29-24/h1-10,13-15,17-18,23,32H,11-12,16H2,(H,30,33)(H,31,34)/t23-/m0/s1
PubChem CID46853632
ChEMBLCHEMBL2164850
IUPHARN/A
BindingDB50395776
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501.8 nMPMID22926069BindingDB,ChEMBL
Emax81.0 %PMID22926069ChEMBL

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