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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1773295
Molecular formula	C22H25N7O3S
IUPAC name	5-[1-[1-(4-methylsulfonylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]piperidin-4-yl]-3-propan-2-yl-1,2,4-oxadiazole
Molecular weight	467.548
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	3.2
Synonyms	3-isopropyl-5-(1-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)piperidin-4-yl)-1,2,4-oxadiazole BDBM50343432
Inchi Key	BNVFIBOYMRSXMI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N7O3S/c1-14(2)19-26-22(32-27-19)15-8-10-28(11-9-15)20-18-12-25-29(21(18)24-13-23-20)16-4-6-17(7-5-16)33(3,30)31/h4-7,12-15H,8-11H2,1-3H3
PubChem CID	54586012
ChEMBL	CHEMBL1773295
IUPHAR	N/A
BindingDB	50343432
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	42.0 nM	PMID21444206	BindingDB,ChEMBL

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