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Name | Gonadotropin-releasing hormone receptor |
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Species | Homo sapiens (Human) |
Gene | GNRHR |
Synonym | LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R [ Show all ] |
Disease | Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease [ Show all ] |
Length | 328 |
Amino acid sequence | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30968 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30968 |
3D structure model | This predicted structure model is from GPCR-EXP P30968. |
BioLiP | N/A |
Therapeutic Target Database | T12475 |
ChEMBL | CHEMBL1855 |
IUPHAR | 256 |
DrugBank | BE0000203 |
Name | CHEMBL111933 |
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Molecular formula | C29H28F3N3O3 |
IUPAC name | 1-[(2,6-difluorophenyl)methyl]-3-[(2R)-1-[(3-fluorophenyl)methylamino]propan-2-yl]-5-(3-methoxyphenyl)-6-methylpyrimidine-2,4-dione |
Molecular weight | 523.556 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 1 |
XlogP | 4.7 |
Synonyms | BDBM50132749 1-(2,6-Difluorobenzyl)-3-[(R)-1-methyl-2-(3-fluorobenzylamino)ethyl]-5-(3-methoxyphenyl)-6-methyluracil 1-(2,6-Difluoro-benzyl)-3-[(R)-2-(3-fluoro-benzylamino)-1-methyl-ethyl]-5-(3-methoxy-phenyl)-6-methyl-1H-pyrimidine-2,4-dione |
Inchi Key | BNVVTOQKKGNWTP-GOSISDBHSA-N |
Inchi ID | InChI=1S/C29H28F3N3O3/c1-18(15-33-16-20-7-4-9-22(30)13-20)35-28(36)27(21-8-5-10-23(14-21)38-3)19(2)34(29(35)37)17-24-25(31)11-6-12-26(24)32/h4-14,18,33H,15-17H2,1-3H3/t18-/m1/s1 |
PubChem CID | 44340824 |
ChEMBL | CHEMBL111933 |
IUPHAR | N/A |
BindingDB | 50132749 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 85.0 nM | PMID12951117 | BindingDB,ChEMBL |
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