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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesRattus norvegicus (Rat)
GeneHtr1d
SynonymHT1DA
5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
5-HT-1D
Htr1db
5-HT1D
[ Show all ]
DiseaseN/A for non-human GPCRs
Length374
Amino acid sequenceMSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS
UniProtP28565
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5450
IUPHAR3
DrugBankN/A

Ligand

NameCyanopindolol
Molecular formulaC16H21N3O2
IUPAC name4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
Molecular weight287.363
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP2.0
Synonyms69906-85-0
CYANOPINDOLOL HEMIFUMARATE
4-[3-(tert-butylamino)-2-hydroxypropoxy]-1H-indole-2-carbonitrile
(+-)-Cyanopindolol
(-)-Cyanopindolol
[ Show all ]
Inchi KeyQXIUMMLTJVHILT-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H21N3O2/c1-16(2,3)18-9-12(20)10-21-15-6-4-5-14-13(15)7-11(8-17)19-14/h4-7,12,18-20H,9-10H2,1-3H3
PubChem CID155346
ChEMBLCHEMBL378501
IUPHAR132
BindingDB81499
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki36.3 nMPMID7984267BindingDB

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