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GPCR

NameNeuropeptide FF receptor 2
SpeciesRattus norvegicus (Rat)
GeneNpffr2
SynonymF8Famide receptor
G protein-coupled receptor 74
G-protein coupled receptor 74
GPR74
Neuropeptide G-protein coupled receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length417
Amino acid sequenceMGKRWDSNSSGSWDHIWSGNDTQHPWYSDINITYMNYYLHQPHVTAVFISSYFLIFFLCMVGNTVVCFVVIRNRYMHTVTNFFIFNLAISDLLVGIFCMPITLLDNIIAGWPFGSSMCKISGLVQGISVAASVFTLVAIAVDRFRCVVYPFKPKLTVKTAFVMIVIIWGLAITIMTPSAIMLHVQEEKYYRVRLSSHNKTSTVYWCREDWPNQEMRRIYTTVLFATIYLAPLSLIVIMYARIGASLFKTSAHSTGKQRLEQWHVSKKKQKVIKMLLTVALLFILSWLPLWTLMMLSDYADLSPNKLRVINIYVYPFAHWLAFCNSSVNPIIYGFFNENFRSGFQDAFQFCQKKVKPQEAYGLRAKRNLDINTSGLLVHEPASQNPSGENLGCRKSADNPTQESLMEETGEATNSTET
UniProtQ9EQD2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3425
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL266976
Molecular formulaC51H71N13O9
IUPAC name(2S)-1-[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-5-oxopentanoyl]-N-[2-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]pyrrolidine-2-carboxamide
Molecular weight1010.21
Hydrogen bond acceptor11
Hydrogen bond donor11
XlogP0.5
SynonymsBDBM50037576
1-(2-{2-[2-(2-Amino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-3-phenyl-propionylamino}-4-carbamoyl-butyryl)-pyrrolidine-2-carboxylic acid {[1-(1-carbamoyl-2-phenyl-ethylcarbamoyl)-4-guanidino-butylcarbamoyl]-methyl}-amide
Inchi KeyQZFIBSCXURKABF-IFLLZMBLSA-N
Inchi IDInChI=1S/C51H71N13O9/c1-31(2)26-39(62-45(68)35(52)27-32-14-6-3-7-15-32)47(70)63-40(29-34-18-10-5-11-19-34)48(71)60-37(22-23-42(53)65)50(73)64-25-13-21-41(64)49(72)58-30-43(66)59-36(20-12-24-57-51(55)56)46(69)61-38(44(54)67)28-33-16-8-4-9-17-33/h3-11,14-19,31,35-41H,12-13,20-30,52H2,1-2H3,(H2,53,65)(H2,54,67)(H,58,72)(H,59,66)(H,60,71)(H,61,69)(H,62,68)(H,63,70)(H4,55,56,57)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
PubChem CID10373789
ChEMBLCHEMBL266976
IUPHARN/A
BindingDB50037576
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.6 nMPMID7932576BindingDB,ChEMBL

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