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GPCR

NameNeuropeptide Y receptor type 2
SpeciesHomo sapiens (Human)
GeneNPY2R
SynonymNPY2-R
NPY-Y2 receptor
neuropeptide Y receptor type 2
Y2 receptor
DiseaseDiabetes
Metabolic disorders
Obesity
Length381
Amino acid sequenceMGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProtP49146
Protein Data BankN/A
GPCR-HGmod modelP49146
3D structure modelThis predicted structure model is from GPCR-EXP P49146.
BioLiPN/A
Therapeutic Target DatabaseT10670
ChEMBLCHEMBL4018
IUPHAR306
DrugBankBE0002419

Ligand

NameCHEMBL3104212
Molecular formulaC27H35FN4O2
IUPAC name2-[4-[4-[(2-cyclopropylacetyl)amino]-2-fluorophenyl]piperazin-1-yl]-N,N-diethyl-2-phenylacetamide
Molecular weight466.601
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP4.1
SynonymsBDBM50445669
SCHEMBL5079942
Inchi KeyBORLQCCBXQSZKN-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H35FN4O2/c1-3-30(4-2)27(34)26(21-8-6-5-7-9-21)32-16-14-31(15-17-32)24-13-12-22(19-23(24)28)29-25(33)18-20-10-11-20/h5-9,12-13,19-20,26H,3-4,10-11,14-18H2,1-2H3,(H,29,33)
PubChem CID58870727
ChEMBLCHEMBL3104212
IUPHARN/A
BindingDB50445669
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50300.0 nMPMID24365162BindingDB,ChEMBL

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