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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameSR-02000000358
Molecular formulaC21H20N2O3
IUPAC name5-cyclopropyl-4-(4-methoxyphenoxy)-2-(4-methylphenyl)pyridazin-3-one
Molecular weight348.402
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.0
SynonymsSR-02000000358-1
CHEMBL1728621
BDBM75890
cid_46172939
5-cyclopropyl-4-(4-methoxyphenoxy)-2-(p-tolyl)pyridazin-3-one
[ Show all ]
Inchi KeyBOSONUOCNBJILM-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H20N2O3/c1-14-3-7-16(8-4-14)23-21(24)20(19(13-22-23)15-5-6-15)26-18-11-9-17(25-2)10-12-18/h3-4,7-13,15H,5-6H2,1-2H3
PubChem CID46172939
ChEMBLCHEMBL1728621
IUPHARN/A
BindingDB75890
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC506200.0 nM, PubChem BioAssay data set, PMID23079522BindingDB,ChEMBL

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