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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

Name[des-Phe6, Glu9] glucagon
Molecular formulaC139H211N39O47S
IUPAC name(4R)-5-[[(2R)-1-[[(2R)-1-[[(2R)-6-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-4-amino-1-[[(1R,2S)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-[[(2R)-2-[[(2R,3S)-2-[[(2R,3S)-2-[[2-[[(2R)-5-amino-2-[[(2R)-2-amino-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoic acid
Molecular weight3212.5
Hydrogen bond acceptor52
Hydrogen bond donor52
XlogP-17.4
Synonyms[des-His1, des-Phe6, Glu9] glucagon
BDBM50059351
Inchi KeyRCDWAGHZRULWMD-IXNLUFIJSA-N
Inchi IDInChI=1S/C139H211N39O47S/c1-64(2)49-88(122(209)161-87(44-48-226-11)121(208)169-94(55-103(145)191)130(217)178-111(70(10)185)137(224)225)164-126(213)93(54-74-58-152-79-24-16-15-23-77(74)79)168-119(206)85(38-42-102(144)190)162-134(221)108(66(5)6)176-129(216)92(51-71-21-13-12-14-22-71)167-127(214)95(56-106(195)196)170-118(205)84(37-41-101(143)189)155-112(199)67(7)154-115(202)81(26-19-46-150-138(146)147)157-116(203)82(27-20-47-151-139(148)149)159-132(219)98(62-181)173-128(215)96(57-107(197)198)171-123(210)89(50-65(3)4)163-124(211)90(52-72-28-32-75(186)33-29-72)165-117(204)80(25-17-18-45-140)158-131(218)97(61-180)172-125(212)91(53-73-30-34-76(187)35-31-73)166-120(207)86(39-43-105(193)194)160-133(220)99(63-182)174-135(222)110(69(9)184)177-136(223)109(68(8)183)175-104(192)59-153-114(201)83(36-40-100(142)188)156-113(200)78(141)60-179/h12-16,21-24,28-35,58,64-70,78,80-99,108-111,152,179-187H,17-20,25-27,36-57,59-63,140-141H2,1-11H3,(H2,142,188)(H2,143,189)(H2,144,190)(H2,145,191)(H,153,201)(H,154,202)(H,155,199)(H,156,200)(H,157,203)(H,158,218)(H,159,219)(H,160,220)(H,161,209)(H,162,221)(H,163,211)(H,164,213)(H,165,204)(H,166,207)(H,167,214)(H,168,206)(H,169,208)(H,170,205)(H,171,210)(H,172,212)(H,173,215)(H,174,222)(H,175,192)(H,176,216)(H,177,223)(H,178,217)(H,193,194)(H,195,196)(H,197,198)(H,224,225)(H4,146,147,150)(H4,148,149,151)/t67-,68+,69+,70+,78-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,108-,109-,110-,111-/m1/s1
PubChem CID91935445
ChEMBLCHEMBL427744
IUPHARN/A
BindingDB50059351
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %PMID9258362ChEMBL
Activity>0.1 %PMID9258362ChEMBL
IC501000.0 nMPMID9258362BindingDB,ChEMBL
IC502000.0 nMPMID9258362BindingDB,ChEMBL
Kd630.96 nMPMID9258362ChEMBL
Kd794.0 nMPMID9258362BindingDB
Kd794.33 nMPMID9258362ChEMBL

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