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Name | D(1A) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD1 |
Synonym | D1 receptor D1A DADR Gpcr15 dopamine D1 receptor [ Show all ] |
Disease | Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder [ Show all ] |
Length | 446 |
Amino acid sequence | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT |
UniProt | P21728 |
Protein Data Bank | N/A |
GPCR-HGmod model | P21728 |
3D structure model | This predicted structure model is from GPCR-EXP P21728. |
BioLiP | N/A |
Therapeutic Target Database | T22118 |
ChEMBL | CHEMBL2056 |
IUPHAR | 214 |
DrugBank | BE0000020 |
Name | A-86929 |
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Molecular formula | C18H21NO2S |
IUPAC name | (1S,10R)-15-propyl-14-thia-11-azatetracyclo[8.7.0.02,7.013,17]heptadeca-2,4,6,13(17),15-pentaene-4,5-diol |
Molecular weight | 315.431 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 3 |
XlogP | 3.4 |
Synonyms | (5aR,11bS)-4,5,5a,6,7,11b-Hexahydro-2-propylbenzo(f)thieno(2,3-C)quinoline-9,10-diol Di-deacetyl adrogolide UNII-S3ZIH99X6E 171961-95-8 S3ZIH99X6E [ Show all ] |
Inchi Key | REHAKLRYABHSQJ-KDOFPFPSSA-N |
Inchi ID | InChI=1S/C18H21NO2S/c1-2-3-11-7-13-17(22-11)9-19-14-5-4-10-6-15(20)16(21)8-12(10)18(13)14/h6-8,14,18-21H,2-5,9H2,1H3/t14-,18+/m1/s1 |
PubChem CID | 9841398 |
ChEMBL | CHEMBL28338 |
IUPHAR | N/A |
BindingDB | 50033114 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 9.0 nM | PMID7658429, PMID10360732 | BindingDB,ChEMBL |
IA | 125.0 % | PMID7658429 | ChEMBL |
Intrinsic activity | 125.0 % | PMID10360732 | ChEMBL |
Ki | 49.0 nM | PMID10360732, PMID7658429 | BindingDB,ChEMBL |
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