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BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13

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GPCR

NameD(1B) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD5
SynonymD(5) dopamine receptor
Dopamine D5 receptor
Gpcr1
D(1B) dopamine receptor
dopamine receptor 5
[ Show all ]
DiseaseSchizophrenia
Solid tumours
Length477
Amino acid sequenceMLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProtP21918
Protein Data BankN/A
GPCR-HGmod modelP21918
3D structure modelThis predicted structure model is from GPCR-EXP P21918.
BioLiPN/A
Therapeutic Target DatabaseT46828
ChEMBLCHEMBL1850
IUPHAR218
DrugBankBE0004889, BE0000145

Ligand

NameCHEMBL3289653
Molecular formulaC21H23ClN2O
IUPAC name1-[3-(1-benzofuran-2-yl)propyl]-4-(4-chlorophenyl)piperazine
Molecular weight354.878
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.2
SynonymsBDBM50017974
Inchi KeyBPHVHUHFXREQBY-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23ClN2O/c22-18-7-9-19(10-8-18)24-14-12-23(13-15-24)11-3-5-20-16-17-4-1-2-6-21(17)25-20/h1-2,4,6-10,16H,3,5,11-15H2
PubChem CID90644066
ChEMBLCHEMBL3289653
IUPHARN/A
BindingDB50017974
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition>50.0 %PMID24800940ChEMBL

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