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GPCR

NameMuscarinic acetylcholine receptor M3
SpeciesRattus norvegicus (Rat)
GeneChrm3
SynonymM3R
Chrm-3
cholinergic receptor
cholinergic receptor, muscarinic 3, cardiac
HM4
[ Show all ]
DiseaseN/A for non-human GPCRs
Length589
Amino acid sequenceMTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
UniProtP08483
Protein Data Bank5zhp, 4u16, 4u14, 4daj, 4u15
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5zhp.
BioLiPBL0300355,BL0300356, BL0300353,BL0300354, BL0223908,BL0223909,BL0223910,, BL0300352, BL0433838,BL0433839, BL0433837
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL320
IUPHAR15
DrugBankN/A

Ligand

NameCHEMBL553066
Molecular formulaC17H23ClN2O3
IUPAC name(8-methanimidoyl-8-azabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;hydrochloride
Molecular weight338.832
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogPNone
SynonymsN/A
Inchi KeyADQPXRMTYWTANH-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H22N2O3.ClH/c18-11-19-13-6-7-14(19)9-15(8-13)22-17(21)16(10-20)12-4-2-1-3-5-12;/h1-5,11,13-16,18,20H,6-10H2;1H
PubChem CID45260599
ChEMBLCHEMBL553066
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Kd1.4 nMPMID2374141ChEMBL

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