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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesHomo sapiens (Human)
GeneHTR1A
Synonym5-HT1A receptor
ADRB2RL1
ADRBRL1
serotonin receptor 1A
5-HT1A
[ Show all ]
DiseaseMajor depressive disorder; Episode; Anxiety
Migraine
Mood disorder
Pain
Parkinson's disease
[ Show all ]
Length422
Amino acid sequenceMDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
UniProtP08908
Protein Data BankN/A
GPCR-HGmod modelP08908
3D structure modelThis predicted structure model is from GPCR-EXP P08908.
BioLiPN/A
Therapeutic Target DatabaseT78709
ChEMBLCHEMBL214
IUPHAR1
DrugBankBE0000291

Ligand

Namemethiothepin
Molecular formulaC20H24N2S2
IUPAC name1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine
Molecular weight356.546
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.2
SynonymsMetitepine
Methiothepine
Metitepinum
Metitepina
Metitepine [INN]
[ Show all ]
Inchi KeyRLJFTICUTYVZDG-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
PubChem CID4106
ChEMBLCHEMBL93240
IUPHAR89
BindingDB78940
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5071.0 nMPMID27487565BindingDB
Ki2.2 nMPMID12519065BindingDB,ChEMBL
Ki4.6 nMPMID27692547BindingDB,ChEMBL
Ki7.94328 - 15.8489 nMPMID9760039, PMID9550290IUPHAR
Ki22.2 nMPMID8461029PDSP,BindingDB
Ki22.38 nMPMID7984267PDSP,BindingDB
Ki24.54 nMPMID7984267PDSP,BindingDB
Ki24.6 nMPMID8461029PDSP,BindingDB
Ki79.43 nMPMID7984267PDSP,BindingDB

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