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GPCR

Name5-hydroxytryptamine receptor 1F
SpeciesRattus norvegicus (Rat)
GeneHtr1f
SynonymHTR1EL
5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
5-HT6
5-HT1F receptor
5-HT1F
[ Show all ]
DiseaseN/A for non-human GPCRs
Length366
Amino acid sequenceMDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINCLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQGLCDLWLSVDIICCTCSILHLSAIALDRYRAITDAVEYARKRTPRHAGITITTVWVISVFISVPPLFWRHQGNSRDDQCIIKHDHIVSTIYSTFGAFYIPLVLILILYYKIYRAARTLYHKRQASRMIKEELNGQVLLESGEKSIKLVSTSYMLEKSLSDPSTDFDRIHSTVKSPRSELKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNICEKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRN
UniProtP30940
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4646
IUPHAR5
DrugBankN/A

Ligand

Namemethiothepin
Molecular formulaC20H24N2S2
IUPAC name1-methyl-4-(3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl)piperazine
Molecular weight356.546
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.2
SynonymsAB00053700
Tox21_110916_1
BPBio1_001352
C20H24N2S2
Dibenzo(b,f)thiepin, 10,11-dihydro-10-(4-methylpiperazinyl)-8-(methylthio)- (+-)
[ Show all ]
Inchi KeyRLJFTICUTYVZDG-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24N2S2/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20/h3-8,14,18H,9-13H2,1-2H3
PubChem CID4106
ChEMBLCHEMBL93240
IUPHAR89
BindingDB78940
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki1000.0 nMPMID7984267BindingDB

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