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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H2 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH2
Synonym	Gastric receptor I H2R HH2R
Disease	N/A for non-human GPCRs
Length	359
Amino acid sequence	MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSLAVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNEVYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVMGAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYHQLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
UniProt	P47747
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2882
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL311272
Molecular formula	C23H31N3O2
IUPAC name	1-(4-methylphenyl)-3-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]urea
Molecular weight	381.52
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.9
Synonyms	1-[3-[3-(Piperidinomethyl)phenoxy]propyl]-3-(4-methylphenyl)urea BDBM50406646
Inchi Key	BPVQCNKNVGULBA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H31N3O2/c1-19-9-11-21(12-10-19)25-23(27)24-13-6-16-28-22-8-5-7-20(17-22)18-26-14-3-2-4-15-26/h5,7-12,17H,2-4,6,13-16,18H2,1H3,(H2,24,25,27)
PubChem CID	14514733
ChEMBL	CHEMBL311272
IUPHAR	N/A
BindingDB	50406646
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	630.96 nM	PMID1352351	BindingDB,ChEMBL

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