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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | CHEMBL272395 |
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Molecular formula | C17H18BrN5 |
IUPAC name | 3-[[4-(6-bromopyridin-2-yl)piperazin-1-yl]methyl]pyrazolo[1,5-a]pyridine |
Molecular weight | 372.27 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 2.8 |
Synonyms | BDBM50373494 |
Inchi Key | RMXWGHDSQFWKHG-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H18BrN5/c18-16-5-3-6-17(20-16)22-10-8-21(9-11-22)13-14-12-19-23-7-2-1-4-15(14)23/h1-7,12H,8-11,13H2 |
PubChem CID | 24823921 |
ChEMBL | CHEMBL272395 |
IUPHAR | N/A |
BindingDB | 50373494 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 150.0 nM | PMID18307287 | BindingDB,ChEMBL |
Ki | 210.0 nM | PMID18307287 | BindingDB,ChEMBL |
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