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GPCR

Name	Histamine H1 receptor
Species	Cavia porcellus (Guinea pig)
Gene	HRH1
Synonym	H1R HH1R
Disease	N/A for non-human GPCRs
Length	488
Amino acid sequence	MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
UniProt	P31389
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3943
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Histaprodifen
Molecular formula	C20H23N3
IUPAC name	2-[2-(3,3-diphenylpropyl)-1H-imidazol-5-yl]ethanamine
Molecular weight	305.425
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	3.5
Synonyms	2-[2-(3,3-diphenylpropyl)-1h-imidazol-4-yl]ethanamine GTPL4026 ZINC38881558 CHEMBL275507 2-[2-[3,3-di(phenyl)propyl]-3H-imidazol-4-yl]ethanamine BDBM22864 2-[2-(3,3-diphenylpropyl)-1H-imidazol-4-yl]ethan-1-amine D0RG8O SCHEMBL3019488 [ Show all ]
Inchi Key	BPZGZNLONLANFE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H23N3/c21-14-13-18-15-22-20(23-18)12-11-19(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,15,19H,11-14,21H2,(H,22,23)
PubChem CID	10447834
ChEMBL	CHEMBL275507
IUPHAR	4026
BindingDB	22864
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Parameter	Value	Reference	Database source
Concentration	3.0 uM	PMID14640554	ChEMBL
Concentration	30.0 nM	PMID10737740	ChEMBL
Concentration	30.0 uM	PMID10737740	ChEMBL
EC50	158.49 nM	PMID14640554	ChEMBL
EC50	181.97 nM	PMID14640554, PMID10737740	ChEMBL
EC50	309.03 nM	PMID10737740	ChEMBL
EC50	1949.84 nM	PMID10737740	ChEMBL
Emax	72.0 -	PMID10737740	ChEMBL
Emax	84.0 %	PMID14640554	ChEMBL
Emax	84.0 -	PMID10737740	ChEMBL
Emax	100.0 %	PMID14640554	ChEMBL
Emax	100.0 -	PMID10737740	ChEMBL
Kd	0.776 nM	PMID10737740	BindingDB
Kd	0.7762 nM	PMID10737740	ChEMBL
Kd	0.977 nM	PMID10737740	BindingDB
Kd	0.9772 nM	PMID10737740	ChEMBL
Kd	1.58 nM	PMID10737740	BindingDB
Kd	1.585 nM	PMID10737740	ChEMBL
pKp	6.04 -	PMID14640554, PMID10737740	ChEMBL
Relative potency	101.0 -	PMID14640554, PMID10737740	ChEMBL
Relative potency	111.0 -	PMID14640554, PMID10737740	ChEMBL
Relative potency	115.0 -	PMID10737740	ChEMBL