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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H4 receptor
Species	Mus musculus (Mouse)
Gene	Hrh4
Synonym	GPCR105 H4 receptor H4R HH4R
Disease	N/A for non-human GPCRs
Length	391
Amino acid sequence	MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProt	Q91ZY2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5657
IUPHAR	265
DrugBank	N/A

Ligand

Name	CHEMBL503605
Molecular formula	C13H14ClN3O
IUPAC name	(5-chloro-1H-indol-2-yl)-piperazin-1-ylmethanone
Molecular weight	263.725
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.8
Synonyms	RNGVSSIIHLHHSN-UHFFFAOYSA-N BB 0247847 (5-Chloro-1H-indol-2-yl)-piperazin-1-yl-metha none 5-chloro-2-(piperazin-1-ylcarbonyl)-1H-indole SCHEMBL6130879 BDBM26391 (5-Chloro-1H-indol-2-yl)-piperazin-1-yl-methanone JNJ 7777120 analogue, 4 AKOS016342960 ZINC32500347 (5-chloro-1H-indol-2-yl)(piperazino)methanone [ Show all ]
Inchi Key	RNGVSSIIHLHHSN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H14ClN3O/c14-10-1-2-11-9(7-10)8-12(16-11)13(18)17-5-3-15-4-6-17/h1-2,7-8,15-16H,3-6H2
PubChem CID	21638785
ChEMBL	CHEMBL503605
IUPHAR	N/A
BindingDB	26391
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	17.78 nM	PMID18817367	ChEMBL

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