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GPCR

NameCannabinoid receptor 2
SpeciesHomo sapiens (Human)
GeneCNR2
SynonymPeripheral cannabinoid receptor
rCB2
hCB2
cannabinoid receptor 2 (macrophage)
cannabinoid receptor 2 (spleen)
[ Show all ]
DiseaseImmune disorder
Inflammatory bowel disease
Inflammatory disease
Neuropathic pain
Osteoporosis
[ Show all ]
Length360
Amino acid sequenceMEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
UniProtP34972
Protein Data Bank5zty
GPCR-HGmod modelP34972
3D structure modelThis structure is from PDB ID 5zty.
BioLiPBL0438927
Therapeutic Target DatabaseT37693
ChEMBLCHEMBL253
IUPHAR57
DrugBankBE0000095

Ligand

NameCHEMBL3114514
Molecular formulaC21H16FN3O
IUPAC nameN-[(2-fluorophenyl)methyl]-4-phenyl-1H-benzimidazole-2-carboxamide
Molecular weight345.377
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP4.3
SynonymsBDBM50005280
Inchi KeyADRLYNCWOAOXPX-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H16FN3O/c22-17-11-5-4-9-15(17)13-23-21(26)20-24-18-12-6-10-16(19(18)25-20)14-7-2-1-3-8-14/h1-12H,13H2,(H,23,26)(H,24,25)
PubChem CID76321459
ChEMBLCHEMBL3114514
IUPHARN/A
BindingDB50005280
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50256.0 nMPMID24461289BindingDB,ChEMBL
Emax49.0 %PMID24461289ChEMBL

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