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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701950
Molecular formulaC20H20ClN3O
IUPAC nameN-[(2-chloroquinolin-3-yl)methyl]-4-[(2S)-morpholin-2-yl]aniline
Molecular weight353.85
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP3.7
SynonymsBDBM129409
SCHEMBL12609839
US8802673, 51
Inchi KeyBQDOGNWVKQRWBL-LJQANCHMSA-N
Inchi IDInChI=1S/C20H20ClN3O/c21-20-16(11-15-3-1-2-4-18(15)24-20)12-23-17-7-5-14(6-8-17)19-13-22-9-10-25-19/h1-8,11,19,22-23H,9-10,12-13H2/t19-/m1/s1
PubChem CID86766836
ChEMBLCHEMBL3701950
IUPHARN/A
BindingDB129409
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki280.3 nM, NoneBindingDB,ChEMBL

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