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GPCR

NameSomatostatin receptor type 5
SpeciesHomo sapiens (Human)
GeneSSTR5
SynonymSOMATO
SS-5-R
SS5-R
SS5R
SST5 receptor
DiseaseN/A
Length364
Amino acid sequenceMEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL
UniProtP35346
Protein Data BankN/A
GPCR-HGmod modelP35346
3D structure modelThis predicted structure model is from GPCR-EXP P35346.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1792
IUPHAR359
DrugBankBE0002147

Ligand

NameCHEMBL236787
Molecular formulaC28H28FN5
IUPAC name1-[(4-fluorophenyl)methyl]-N-[1-(1H-indol-5-ylmethyl)piperidin-4-yl]benzimidazol-2-amine
Molecular weight453.565
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP5.7
SynonymsBDBM50227101
N-(1-((1H-indol-5-yl)methyl)piperidin-4-yl)-1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-amine
Inchi KeyADRXLGLHNMXDTH-UHFFFAOYSA-N
Inchi IDInChI=1S/C28H28FN5/c29-23-8-5-20(6-9-23)19-34-27-4-2-1-3-26(27)32-28(34)31-24-12-15-33(16-13-24)18-21-7-10-25-22(17-21)11-14-30-25/h1-11,14,17,24,30H,12-13,15-16,18-19H2,(H,31,32)
PubChem CID24740521
ChEMBLCHEMBL236787
IUPHARN/A
BindingDB50227101
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki3950.0 nMPMID18020390BindingDB,ChEMBL

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