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GPCR

NameMu-type opioid receptor
SpeciesRattus norvegicus (Rat)
GeneOprm1
SynonymOpioid receptor B
opioid receptor
OP3
mu receptor
MOR-1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length398
Amino acid sequenceMDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProtP33535
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL270
IUPHAR319
DrugBankN/A

Ligand

Namemorphine
Molecular formulaC17H19NO3
IUPAC name(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight285.343
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP0.8
SynonymsSDZ202-250
ZINC3812983
Morphine Forte
76I7G6D29C
Morphinum
[ Show all ]
Inchi KeyBQJCRHHNABKAKU-KBQPJGBKSA-N
Inchi IDInChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
PubChem CID5288826
ChEMBLCHEMBL70
IUPHAR1627
BindingDB50000092
DrugBankDB00295

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity209.0 %PMID19932964ChEMBL
EC5021.0 nMPMID9873603BindingDB
EC5021.3 nMPMID9873603ChEMBL
EC50123.5 nMPMID19932964BindingDB,ChEMBL
EC50194.0 nMPMID23419026BindingDB,ChEMBL
Emax57.0 %PMID23419026ChEMBL
Emax134.0 %PMID18062664ChEMBL
IC500.14 nMPMID7739011ChEMBL
IC500.14 nMPMID7739011BindingDB
IC501.6 nMPMID1671414BindingDB,ChEMBL
IC501.9 nMPMID8642567, PMID7739011BindingDB
IC501.94 nMPMID7739011, PMID8642567ChEMBL
IC503.9 nMPMID1851843BindingDB,ChEMBL
IC505.64 nMPMID20413312BindingDB,ChEMBL
IC509770.0 nMPMID18370374BindingDB,ChEMBL
Ki<10000.0 nMPMID20580236, PMID7562497BindingDB,ChEMBL
Ki0.3 nMPMID3033464BindingDB
Ki0.4 nMPMID3033464BindingDB
Ki0.78 nMPMID12643945ChEMBL
Ki0.78 nMPMID12643945BindingDB
Ki0.82 nMPMID9694962BindingDB
Ki1.0 nMPMID12570383BindingDB,ChEMBL
Ki1.04 nMPMID9694962BindingDB
Ki1.24 nMPMID7562497BindingDB
Ki1.45 nMPMID25129170ChEMBL
Ki1.5 nMPMID25129170BindingDB
Ki1.8 nMPMID11425550, PMID10843229BindingDB,ChEMBL
Ki2.0 nMPMID8064796BindingDB,ChEMBL
Ki2.1 nMPMID2170652BindingDB,ChEMBL
Ki2.15 nMPMID2828622BindingDB,ChEMBL
Ki2.8 nMPMID10841790BindingDB,ChEMBL
Ki3.0 nM, Bioorg. Med. Chem. Lett., (1995) 5:6:589BindingDB,ChEMBL
Ki4.8 nMPMID12643945BindingDB,ChEMBL
Ki5.7 nMPMID2831363BindingDB,ChEMBL
Ki6.3 nMPMID23419026BindingDB,ChEMBL
Ki6.55 nMPMID15857143, PMID12699394, PMID16033285, PMID12954070, PMID21235243BindingDB,ChEMBL
Ki6.6 nMPMID21235243BindingDB
Ki8.1 nMPMID7739013BindingDB
Ki8.14 nMPMID7739013ChEMBL
Ki11.0 nMPMID14998329BindingDB,ChEMBL
Ki12.5893 nMPMID8114680IUPHAR
Ki22.0 nMPMID7815359BindingDB
Ki36.0 nMPMID8390575BindingDB,ChEMBL
Ki116.8 nMPMID19932964BindingDB,ChEMBL
KiH2.5 nMPMID19351163ChEMBL
KiL113.0 nMPMID19351163ChEMBL
Kp12.6 -PMID2831361ChEMBL
Kp300000.0 -PMID2999404ChEMBL
KT18.8 -PMID2831361ChEMBL
Kt150000000.0 -PMID2999404ChEMBL
ln Kp12.6 -PMID2999404ChEMBL
ln Kt18.8 -PMID2999404ChEMBL
Log10ED507.09 -PMID18062664ChEMBL

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