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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Histamine H2 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh2
Synonym	gastric receptor I H2 receptor H2R HH2R
Disease	N/A for non-human GPCRs
Length	358
Amino acid sequence	MEPNGTVHSCCLDSMALKVTISVVLTTLILITIAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVLPFSAIYQLSFTWSFGHVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGLVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEAVEGIVLWLGYANSALNPILYAALNRDFRTAYQQLFHCKFASHNSHKTSLRLNNSLLPRSQSREGRWQEEKPLKLQVWSGTELTHPQGNPIR
UniProt	P25102
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4654
IUPHAR	263
DrugBank	N/A

Ligand

Name	CHEMBL3228811
Molecular formula	C21H31N3O
IUPAC name	5,7-dimethyl-1-[2-(2,2,6,6-tetramethylpiperidin-1-yl)ethyl]-1,8-naphthyridin-2-one
Molecular weight	341.499
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.7
Synonyms	N/A
Inchi Key	RYIIUGUFAKFLGV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H31N3O/c1-15-14-16(2)22-19-17(15)8-9-18(25)23(19)12-13-24-20(3,4)10-7-11-21(24,5)6/h8-9,14H,7,10-13H2,1-6H3
PubChem CID	90668677
ChEMBL	CHEMBL3228811
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Inhibition	>30.0 %	PMID423213	ChEMBL

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