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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 1D
Species	Cavia porcellus (Guinea pig)
Gene	HTR1D
Synonym	5-HT-1D 5-HT1D Serotonin receptor 1D
Disease	N/A for non-human GPCRs
Length	376
Amino acid sequence	MSPPNQSEEGLPQEASNRSLNATETPGDWDPGLLQALKVSLVVVLSIITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAGAMIAAVWVISICISIPPLFWRQAQAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYSRIYRAARSRILNPPSLSGKRFTTAHLITGSAGSSLCSLNPSLHEGHMHPGSPLFFNHVRIKLADSVLERKRISAARERKATKTLGIILGAFIVCWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEDFRQAFQKVVHFRKAS
UniProt	Q60484
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2304407
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL73446
Molecular formula	C30H36N2O5
IUPAC name	2-methoxyethyl 4-[4-[[3-[3-(dimethylamino)propyl]-4-methoxybenzoyl]amino]phenyl]-3-methylbenzoate
Molecular weight	504.627
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	5.1
Synonyms	4'-[[3-[3-(Dimethylamino)propyl]-4-methoxybenzoyl]amino]-2-methyl-1,1'-biphenyl-4-carboxylic acid 2-methoxyethyl ester SCHEMBL6502023
Inchi Key	RYJKLOQHRYQMKA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H36N2O5/c1-21-19-25(30(34)37-18-17-35-4)10-14-27(21)22-8-12-26(13-9-22)31-29(33)24-11-15-28(36-5)23(20-24)7-6-16-32(2)3/h8-15,19-20H,6-7,16-18H2,1-5H3,(H,31,33)
PubChem CID	10346019
ChEMBL	CHEMBL73446
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
ED50	45.0 mg.kg-1	PMID8057272	ChEMBL
Inhibition	55.0 %	PMID8057272	ChEMBL
Inhibition	66.0 %	PMID8057272	ChEMBL
Ki	3.162 nM	PMID8057272	ChEMBL

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