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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL216050
Molecular formulaC26H29N3O
IUPAC nameN-[(2S)-6-[(dimethylamino)methyl]-1,2,3,4-tetrahydronaphthalen-2-yl]-N-methyl-4-pyridin-4-ylbenzamide
Molecular weight399.538
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.2
SynonymsBDBM50198488
(S)-N-(6-((dimethylamino)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)-N-methyl-4-(pyridin-4-yl)benzamide
Inchi KeyADTVOYHHLZXZMB-VWLOTQADSA-N
Inchi IDInChI=1S/C26H29N3O/c1-28(2)18-19-4-5-24-17-25(11-10-23(24)16-19)29(3)26(30)22-8-6-20(7-9-22)21-12-14-27-15-13-21/h4-9,12-16,25H,10-11,17-18H2,1-3H3/t25-/m0/s1
PubChem CID44417900
ChEMBLCHEMBL216050
IUPHARN/A
BindingDB50198488
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2480.0 nMPMID17107791BindingDB,ChEMBL

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