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GPCR

NameAlpha-2A adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2A
Synonymalpha2D
alpha2A-AR
alpha2A-adrenoceptor
alpha2A-adrenergic receptor
alpha2A
[ Show all ]
DiseaseAttention deficit hyperactivity disorder
Sexual dysfunction
Pain
Length450
Amino acid sequenceMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKAWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPLISIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDAVAAPPGGTERRPNGLGPERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESSSSDHAERPPGPRRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLTAVGCSVPRTLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtP08913
Protein Data BankN/A
GPCR-HGmod modelP08913
3D structure modelThis predicted structure model is from GPCR-EXP P08913.
BioLiPN/A
Therapeutic Target DatabaseT11448
ChEMBLCHEMBL1867
IUPHAR25
DrugBankBE0000289

Ligand

NameCHEMBL138809
Molecular formulaC20H23NO2
IUPAC name1'-benzyl-1-methoxyspiro[1H-2-benzofuran-3,4'-piperidine]
Molecular weight309.409
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.0
Synonyms1'-Benzyl-3-methoxyspiro[isobenzofuran-1(3H),4'-piperidine]
1''-benzyl-3-methoxyspiro[1,3-dihydroisobenzofuran-1,4''-(hexahydropyridine)]
1''-benzyl-3-methoxy-3H-spiro[2-benzofuran-1,4''-piperidine]
1'-benzyl-3-methoxy-3h-spiro[[2]benzofuran-1,4'-piperidine]
BDBM50108659
[ Show all ]
Inchi KeyRZZAEVQHACUOGI-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H23NO2/c1-22-19-17-9-5-6-10-18(17)20(23-19)11-13-21(14-12-20)15-16-7-3-2-4-8-16/h2-10,19H,11-15H2,1H3
PubChem CID10357986
ChEMBLCHEMBL138809
IUPHARN/A
BindingDB50108659
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC506200.0 nMPMID11784148BindingDB,ChEMBL

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