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GPCR

NameC-C chemokine receptor type 8
SpeciesHomo sapiens (Human)
GeneCCR8
SynonymGPRCY6
GPR-CY6
CMKBRL2
CKR-L1
ChemR1
[ Show all ]
DiseasePsoriasis
Length355
Amino acid sequenceMDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGVLQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
UniProtP51685
Protein Data BankN/A
GPCR-HGmod modelP51685
3D structure modelThis predicted structure model is from GPCR-EXP P51685.
BioLiPN/A
Therapeutic Target DatabaseT20575
ChEMBLCHEMBL4596
IUPHAR65
DrugBankN/A

Ligand

NameCHEMBL374527
Molecular formulaC31H38N4O5S
IUPAC name3-pyrrolidin-1-ylpropyl 4-[[4-[(2-methylbenzoyl)amino]naphthalen-1-yl]sulfonylamino]piperidine-1-carboxylate
Molecular weight578.728
Hydrogen bond acceptor7
Hydrogen bond donor2
XlogP4.7
SynonymsBDBM50203869
3-pyrrolidin-1-ylpropyl 4-[({4-[(2-methylbenzoyl)amino]-1-naphthyl}sulfonyl)amino]piperidine-1-carboxylate
Inchi KeyBRFSLLFZOHATFX-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H38N4O5S/c1-23-9-2-3-10-25(23)30(36)32-28-13-14-29(27-12-5-4-11-26(27)28)41(38,39)33-24-15-20-35(21-16-24)31(37)40-22-8-19-34-17-6-7-18-34/h2-5,9-14,24,33H,6-8,15-22H2,1H3,(H,32,36)
PubChem CID16105817
ChEMBLCHEMBL374527
IUPHARN/A
BindingDB50203869
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC504.2 nMPMID17266208BindingDB,ChEMBL

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