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GPCR

NameProkineticin receptor 2
SpeciesHomo sapiens (Human)
GenePROKR2
SynonymPKR2
PK-R2
I5E
GPRg2
GPR73b
[ Show all ]
DiseaseN/A
Length384
Amino acid sequenceMAAQNGNTSFTPNFNPPQDHASSLSFNFSYGDYDLPMDEDEDMTKTRTFFAAKIVIGIALAGIMLVCGIGNFVFIAALTRYKKLRNLTNLLIANLAISDFLVAIICCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLKPRMNYQTASFLIALVWMVSILIAIPSAYFATETVLFIVKSQEKIFCGQIWPVDQQLYYKSYFLFIFGVEFVGPVVTMTLCYARISRELWFKAVPGFQTEQIRKRLRCRRKTVLVLMCILTAYVLCWAPFYGFTIVRDFFPTVFVKEKHYLTAFYVVECIAMSNSMINTVCFVTVKNNTMKYFKKMMLLHWRPSQRGSKSSADLDLRTNGVPTTEEVDCIRLK
UniProtQ8NFJ6
Protein Data BankN/A
GPCR-HGmod modelQ8NFJ6
3D structure modelThis predicted structure model is from GPCR-EXP Q8NFJ6.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5548
IUPHAR336
DrugBankN/A

Ligand

NameTriazine compound, 2
Molecular formulaC22H27N5O3
IUPAC name6-(2-aminoethylamino)-3-[(4-ethylphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-1,3,5-triazine-2,4-dione
Molecular weight409.49
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.1
Synonyms6-[(2-aminoethyl)amino]-3-[(4-ethylphenyl)methyl]-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydro-1,3,5-triazine-2,4-dione
CHEMBL514895
BDBM26336
SCHEMBL326251
Inchi KeySBCYNSAHFDNMMM-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H27N5O3/c1-3-16-4-6-17(7-5-16)15-27-21(28)25-20(24-13-12-23)26(22(27)29)14-18-8-10-19(30-2)11-9-18/h4-11H,3,12-15,23H2,1-2H3,(H,24,25,28)
PubChem CID25138121
ChEMBLCHEMBL514895
IUPHARN/A
BindingDB26336
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity2.0 %PMID19006379ChEMBL
Activity89.0 %PMID19006379ChEMBL
Ki23422.0 nMPMID19006379BindingDB,ChEMBL

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