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GPCR

NameHydroxycarboxylic acid receptor 2
SpeciesMus musculus (Mouse)
GeneHcar2
SynonymProtein PUMA-G
Nicotinic acid receptor
Nic1
Niacr1
niacin receptor 1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
UniProtQ9EP66
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4420
IUPHAR312
DrugBankN/A

Ligand

NameCHEMBL519338
Molecular formulaC9H12N6
IUPAC name5-ethyl-3-(2H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Molecular weight204.237
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.1
SynonymsSCHEMBL5086041
SCHEMBL14175679
BDBM50277670
5-ethyl-3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[c]pyrazole
Inchi KeySECXDPVXDUGTCU-UHFFFAOYSA-N
Inchi IDInChI=1S/C9H12N6/c1-2-5-3-6-7(4-5)10-11-8(6)9-12-14-15-13-9/h5H,2-4H2,1H3,(H,10,11)(H,12,13,14,15)
PubChem CID11183317
ChEMBLCHEMBL519338
IUPHARN/A
BindingDB50277670
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501300.0 nMPMID19307116BindingDB,ChEMBL

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