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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	C-C chemokine receptor type 3
Species	Homo sapiens (Human)
Gene	CCR3
Synonym	MIP-1alphaRL-2 (mouse) Eosinophil eotaxin receptor CKR3 chemokine (C-C motif) receptor 3 CD193 CCR3 CCR-3 CC-CKR-3 CC CKR3 C-C CKR-3 [ Show all ]
Disease	Allergic asthma Allergic rhinitis Asthma
Length	355
Amino acid sequence	MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
UniProt	P51677
Protein Data Bank	N/A
GPCR-HGmod model	P51677
3D structure model	This predicted structure model is from GPCR-EXP P51677.
BioLiP	N/A
Therapeutic Target Database	T02752, T85228
ChEMBL	CHEMBL3473
IUPHAR	60
DrugBank	N/A

Ligand

Name	CHEMBL385607
Molecular formula	C28H35FN4O4
IUPAC name	2-[(2S,4R)-2-[3-[(3,5-diacetylphenyl)carbamoylamino]propyl]-4-[(4-fluorophenyl)methyl]piperidin-1-yl]acetamide
Molecular weight	510.61
Hydrogen bond acceptor	6
Hydrogen bond donor	3
XlogP	2.9
Synonyms	BDBM50193772 SCHEMBL6773994 1-(3-((2S,4R)-4-(4-fluorobenzyl)-1-(2-amino-2-oxoethyl)piperidin-2-yl)propyl)-3-(3,5-diacetylphenyl)urea
Inchi Key	BRTWZDQCGNRNRK-LVXARBLLSA-N
Inchi ID	InChI=1S/C28H35FN4O4/c1-18(34)22-14-23(19(2)35)16-25(15-22)32-28(37)31-10-3-4-26-13-21(9-11-33(26)17-27(30)36)12-20-5-7-24(29)8-6-20/h5-8,14-16,21,26H,3-4,9-13,17H2,1-2H3,(H2,30,36)(H2,31,32,37)/t21-,26-/m0/s1
PubChem CID	44419299
ChEMBL	CHEMBL385607
IUPHAR	N/A
BindingDB	50193772
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	3.6 nM	PMID16931001	BindingDB,ChEMBL

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