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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesRattus norvegicus (Rat)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length488
Amino acid sequenceMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP43114
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4086
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL383339
Molecular formulaC24H37NO5
IUPAC name7-[(2S)-2-[(3R)-3-hydroxy-4-[3-(2-methoxyethyl)phenyl]butyl]-5-oxopyrrolidin-1-yl]heptanoic acid
Molecular weight419.562
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.1
Synonyms7-((S)-2-((R)-3-hydroxy-4-(3-(2-methoxyethyl)phenyl)butyl)-5-oxopyrrolidin-1-yl)heptanoic acid
BDBM50181278
SCHEMBL4998792
Inchi KeySHDNMDIQJRONIG-FCHUYYIVSA-N
Inchi IDInChI=1S/C24H37NO5/c1-30-16-14-19-7-6-8-20(17-19)18-22(26)12-10-21-11-13-23(27)25(21)15-5-3-2-4-9-24(28)29/h6-8,17,21-22,26H,2-5,9-16,18H2,1H3,(H,28,29)/t21-,22+/m0/s1
PubChem CID44409743
ChEMBLCHEMBL383339
IUPHARN/A
BindingDB50181278
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity82.0 %PMID16442794ChEMBL
EC5092.0 nMPMID16442794BindingDB,ChEMBL
IC50210.0 nMPMID16442794BindingDB,ChEMBL

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