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Name | Adenosine receptor A1 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Adora1 |
Synonym | A1 receptor A1-AR A1R adenosine receptor A1 RDC7 |
Disease | N/A for non-human GPCRs |
Length | 326 |
Amino acid sequence | MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED |
UniProt | P25099 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL318 |
IUPHAR | 18 |
DrugBank | N/A |
Name | ENPROFYLLINE |
---|---|
Molecular formula | C8H10N4O2 |
IUPAC name | 3-propyl-7H-purine-2,6-dione |
Molecular weight | 194.194 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 2 |
XlogP | 0.3 |
Synonyms | Enprofilina FT-0630617 LP00910 NCGC00015824-04 NCGC00022716-05 [ Show all ] |
Inchi Key | SIQPXVQCUCHWDI-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) |
PubChem CID | 1676 |
ChEMBL | CHEMBL279898 |
IUPHAR | N/A |
BindingDB | 50001493 |
DrugBank | DB00824 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Kb | 32000.0 nM | PMID12139454 | ChEMBL |
Ki | <10000.0 nM | PMID3010074, PMID2997628 | BindingDB |
Ki | 32000.0 nM | PMID8230124 | BindingDB,ChEMBL |
Ki | 55000.0 nM | PMID2213834 | BindingDB,ChEMBL |
Ki | 81000.0 nM | PMID2724296 | BindingDB,ChEMBL |
Ki | 156000.0 nM | PMID19569717 | BindingDB,ChEMBL |
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