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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL2381840
Molecular formula	C23H24FN3O4
IUPAC name	3-[[4-[1-[4-(4-fluoropyrazol-1-yl)phenoxy]butyl]benzoyl]amino]propanoic acid
Molecular weight	425.46
Hydrogen bond acceptor	6
Hydrogen bond donor	2
XlogP	3.5
Synonyms	BDBM100790 SCHEMBL11962659 US8507533, 28
Inchi Key	BSIHWVZFJPPICH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H24FN3O4/c1-2-3-21(16-4-6-17(7-5-16)23(30)25-13-12-22(28)29)31-20-10-8-19(9-11-20)27-15-18(24)14-26-27/h4-11,14-15,21H,2-3,12-13H2,1H3,(H,25,30)(H,28,29)
PubChem CID	60152880
ChEMBL	CHEMBL2381840
IUPHAR	N/A
BindingDB	100790
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kb	10000.0 nM	PMID23562063	ChEMBL
Ki	1700.0 nM	PMID23562063	BindingDB,ChEMBL

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