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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameAc-glucagon(6-29)amide
Molecular formulaC135H198N36O41S
IUPAC name(3S)-3-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S,3R)-1,3-dihydroxy-2-[[(2S)-1-hydroxy-2-(1-hydroxyethylideneamino)-3-phenylpropylidene]amino]butylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxypropylidene]amino]-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyhexylidene]amino]-1-hydroxy-3-(4-hydroxyphenyl)propylidene]amino]-1-hydroxy-4-methylpentylidene]amino]-3-carboxy-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-5-carbamimidamido-1-hydroxypentylidene]amino]-1-hydroxypropylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-4-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S)-1-[(2S,3R)-1,3-dihydroxy-1-iminobutan-2-yl]imino-1,4-dihydroxy-4-iminobutan-2-yl]imino-1-hydroxy-4-methylsulfanylbutan-2-yl]imino-1-hydroxy-4-methylpentan-2-yl]imino-1-hydroxy-3-(1H-indol-3-yl)propan-2-yl]imino-1,5-dihydroxy-5-iminopentan-2-yl]imino-1-hydroxy-3-methylbutan-2-yl]imino-1-hydroxy-3-phenylpropan-2-yl]imino-4-hydroxybutanoic acid
Molecular weight3013.34
Hydrogen bond acceptor73
Hydrogen bond donor50
XlogP5.3
SynonymsN/A
Inchi KeySNBXECZRNHIPEF-AHUYCMNKSA-N
Inchi IDInChI=1S/C135H198N36O41S/c1-65(2)50-87(118(197)154-86(45-49-213-11)117(196)162-94(57-103(139)182)128(207)170-108(69(8)175)110(140)189)157-122(201)93(56-76-61-147-80-29-19-18-28-79(76)80)161-116(195)85(42-44-102(138)181)155-132(211)107(67(5)6)169-127(206)92(53-73-26-16-13-17-27-73)160-123(202)95(58-104(183)184)163-115(194)84(41-43-101(137)180)150-111(190)68(7)148-112(191)82(31-22-47-145-134(141)142)151-113(192)83(32-23-48-146-135(143)144)153-130(209)99(63-173)167-125(204)97(60-106(187)188)164-119(198)88(51-66(3)4)156-120(199)90(54-74-33-37-77(178)38-34-74)158-114(193)81(30-20-21-46-136)152-129(208)98(62-172)166-121(200)91(55-75-35-39-78(179)40-36-75)159-124(203)96(59-105(185)186)165-131(210)100(64-174)168-133(212)109(70(9)176)171-126(205)89(149-71(10)177)52-72-24-14-12-15-25-72/h12-19,24-29,33-40,61,65-70,81-100,107-109,147,172-176,178-179H,20-23,30-32,41-60,62-64,136H2,1-11H3,(H2,137,180)(H2,138,181)(H2,139,182)(H2,140,189)(H,148,191)(H,149,177)(H,150,190)(H,151,192)(H,152,208)(H,153,209)(H,154,197)(H,155,211)(H,156,199)(H,157,201)(H,158,193)(H,159,203)(H,160,202)(H,161,195)(H,162,196)(H,163,194)(H,164,198)(H,165,210)(H,166,200)(H,167,204)(H,168,212)(H,169,206)(H,170,207)(H,171,205)(H,183,184)(H,185,186)(H,187,188)(H4,141,142,145)(H4,143,144,146)/t68-,69+,70+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,107-,108-,109-/m0/s1
PubChem CID101110101
ChEMBLCHEMBL437860
IUPHARN/A
BindingDB50098572
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC5031.0 nMPMID11311060BindingDB,ChEMBL
Relative binding4.8 %PMID11311060ChEMBL

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