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Name | Gonadotropin-releasing hormone receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Gnrhr |
Synonym | luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 327 |
Amino acid sequence | MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30969 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3066 |
IUPHAR | 256 |
DrugBank | N/A |
Name | CHEMBL267642 |
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Molecular formula | C80H101ClN16O15 |
IUPAC name | (2R)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-3-(4-acetamidophenyl)propanoyl]amino]-4-methylpentanoyl]amino]-6-(propan-2-ylamino)hexanoyl]-N-[(1R)-2-amino-1-formamido-2-oxoethyl]pyrrolidine-2-carboxamide |
Molecular weight | 1562.23 |
Hydrogen bond acceptor | 17 |
Hydrogen bond donor | 15 |
XlogP | 4.4 |
Synonyms | BDBM50060809 [L or DAgl (formyl)10]acyline |
Inchi Key | BTABKZCJZXLEMX-YTSWYTFXSA-N |
Inchi ID | InChI=1S/C80H101ClN16O15/c1-46(2)36-62(72(104)89-61(17-10-11-34-84-47(3)4)80(112)97-35-13-18-69(97)79(111)96-71(70(82)103)85-45-99)90-74(106)65(39-52-22-29-59(30-23-52)86-48(5)100)92-76(108)66(40-53-24-31-60(32-25-53)87-49(6)101)94-78(110)68(44-98)95-77(109)67(42-55-14-12-33-83-43-55)93-75(107)64(38-51-20-27-58(81)28-21-51)91-73(105)63(88-50(7)102)41-54-19-26-56-15-8-9-16-57(56)37-54/h8-9,12,14-16,19-33,37,43,45-47,61-69,71,84,98H,10-11,13,17-18,34-36,38-42,44H2,1-7H3,(H2,82,103)(H,85,99)(H,86,100)(H,87,101)(H,88,102)(H,89,104)(H,90,106)(H,91,105)(H,92,108)(H,93,107)(H,94,110)(H,95,109)(H,96,111)/t61-,62-,63+,64+,65+,66-,67+,68-,69+,71+/m0/s1 |
PubChem CID | 44348453 |
ChEMBL | CHEMBL267642 |
IUPHAR | N/A |
BindingDB | 50060809 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.62 nM | PMID9371239 | BindingDB,ChEMBL |
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