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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Vasopressin V2 receptor
Species	Rattus norvegicus (Rat)
Gene	Avpr2
Synonym	AVPR V2 Antidiuretic hormone receptor ADHR Renal-type arginine vasopressin receptor V2 receptor V2R DIR3 [ Show all ]
Disease	N/A for non-human GPCRs
Length	371
Amino acid sequence	MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
UniProt	Q00788
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3766
IUPHAR	368
DrugBank	N/A

Ligand

Name	CHEMBL405055
Molecular formula	C56H83N17O12S2
IUPAC name	(2S)-N-[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(10S,13R,16S,19R,22S)-13-(2-amino-2-oxoethyl)-16-(3-amino-3-oxopropyl)-19-benzyl-22-[(4-hydroxyphenyl)methyl]-23-methyl-12,15,18,21,24-pentaoxo-7,8-dithia-11,14,17,20,23-pentazaspiro[5.19]pentacosane-10-carbonyl]pyrrolidine-2-carboxamide
Molecular weight	1250.51
Hydrogen bond acceptor	16
Hydrogen bond donor	14
XlogP	-3.0
Synonyms	N/A
Inchi Key	BTACYYTUKRLXHP-SNQVBUBXSA-N
Inchi ID	InChI=1S/C56H83N17O12S2/c1-72-42(28-33-16-18-34(74)19-17-33)52(84)70-38(27-32-11-4-2-5-12-32)49(81)67-37(20-21-43(57)75)48(80)69-39(29-44(58)76)50(82)71-40(31-86-87-56(30-45(72)77)22-6-3-7-23-56)53(85)73-26-10-15-41(73)51(83)68-36(14-9-25-65-55(62)63)47(79)66-35(46(59)78)13-8-24-64-54(60)61/h2,4-5,11-12,16-19,35-42,74H,3,6-10,13-15,20-31H2,1H3,(H2,57,75)(H2,58,76)(H2,59,78)(H,66,79)(H,67,81)(H,68,83)(H,69,80)(H,70,84)(H,71,82)(H4,60,61,64)(H4,62,63,65)/t35-,36-,37-,38+,39+,40+,41-,42-/m0/s1
PubChem CID	44350546
ChEMBL	CHEMBL405055
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Effective dose	18.0 nM kg-1	PMID1531076	ChEMBL
Kd	6.66 nM	PMID1531076	ChEMBL

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