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Name | G-protein coupled receptor 55 |
---|---|
Species | Homo sapiens (Human) |
Gene | GPR55 |
Synonym | GPR55 |
Disease | N/A |
Length | 319 |
Amino acid sequence | MSQQNTSGDCLFDGVNELMKTLQFAVHIPTFVLGLLLNLLAIHGFSTFLKNRWPDYAATSIYMINLAVFDLLLVLSLPFKMVLSQVQSPFPSLCTLVECLYFVSMYGSVFTICFISMDRFLAIRYPLLVSHLRSPRKIFGICCTIWVLVWTGSIPIYSFHGKVEKYMCFHNMSDDTWSAKVFFPLEVFGFLLPMGIMGFCCSRSIHILLGRRDHTQDWVQQKACIYSIAASLAVFVVSFLPVHLGFFLQFLVRNSFIVECRAKQSISFFLQLSMCFSNVNCCLDVFCYYFVIKEFRMNIRAHRPSRVQLVLQDTTISRG |
UniProt | Q9Y2T6 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y2T6 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y2T6. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075322 |
IUPHAR | 109 |
DrugBank | BE0005802 |
Name | CHEMBL3221189 |
---|---|
Molecular formula | C20H17ClN2O2S |
IUPAC name | (2Z)-2-[[3-[(2-chlorophenyl)methoxy]phenyl]methylidene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3-one |
Molecular weight | 384.878 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 0 |
XlogP | 4.7 |
Synonyms | 2-[3-(2-Chlorobenzyloxy)benzylidene]-2,3,6,7-tetrahydro-5H-imidazo[2,1-b][1,3]thiazine-3-one |
Inchi Key | STEMEZOWSYEKBF-PDGQHHTCSA-N |
Inchi ID | InChI=1S/C20H17ClN2O2S/c21-17-8-2-1-6-15(17)13-25-16-7-3-5-14(11-16)12-18-19(24)23-9-4-10-26-20(23)22-18/h1-3,5-8,11-12H,4,9-10,13H2/b18-12- |
PubChem CID | 90667655 |
ChEMBL | CHEMBL3221189 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 10.0 % | MedChemComm, (2014) 5:5:632 | ChEMBL |
IC50 | 10000.0 nM | MedChemComm, (2014) 5:5:632 | ChEMBL |
Inhibition | 45.0 % | MedChemComm, (2014) 5:5:632 | ChEMBL |
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