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GPCR

NameOxoeicosanoid receptor 1
SpeciesHomo sapiens (Human)
GeneOXER1
SynonymR527
oxoeicosanoid (OXE) receptor 1
OXE receptor
hGPCR48
GPR170
[ Show all ]
DiseaseN/A
Length423
Amino acid sequenceMLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
UniProtQ8TDS5
Protein Data BankN/A
GPCR-HGmod modelQ8TDS5
3D structure modelThis predicted structure model is from GPCR-EXP Q8TDS5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1628461
IUPHAR271
DrugBankN/A

Ligand

NameCHEMBL2332567
Molecular formulaC19H25NO3
IUPAC name5-(2-hexylindol-1-yl)-5-oxopentanoic acid
Molecular weight315.413
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.5
SynonymsSTNXFUFGUJRZHY-UHFFFAOYSA-N
5-(2-Hexyl-indol-1-yl)-5-oxo-pentanoic acid
BDBM50431184
SCHEMBL286740
5-Oxo-5-(2-hexyl-1H-indole-1-yl)pentanoic acid
Inchi KeySTNXFUFGUJRZHY-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25NO3/c1-2-3-4-5-10-16-14-15-9-6-7-11-17(15)20(16)18(21)12-8-13-19(22)23/h6-7,9,11,14H,2-5,8,10,12-13H2,1H3,(H,22,23)
PubChem CID49804576
ChEMBLCHEMBL2332567
IUPHARN/A
BindingDB50431184
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC501130.0 nMPMID24351031BindingDB,ChEMBL
IC501550.0 nMPMID23581530BindingDB,ChEMBL

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