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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	n-Propylapomorphine
Molecular formula	C19H21NO2
IUPAC name	(6aR)-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
Molecular weight	295.382
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.2
Synonyms	(-)-6-Propylnorapomorphine (R)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol 6-Propylnoraporphine-10,11-diol BRD-K13544237-001-01-0 D-027 N-propylnorapomorphine-(-) PDSP2_000840 ZINC2539817 (-)-NPA 4H-Dibenzo[de,g]quinoline-10,11-diol,5,6,6a,7-tetrahydro-6-propyl-, (6aR)- AC1Q7BE4 GTPL969 Noraporphine-10,11-diol, 6-propyl- R-N-PROPYLNORAPOMORPHINE (R) 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol Biomol-NT_000080 cid_11957529 N-Propylnorapomorphine PDSP1_001509 UNII-NH381P1BR8 (+)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (-)-N-porphynorapomorphine 10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium(R(-)NPA) CCG-204527 D06DGY NCGC00162153-03 PDSP2_001493 (6ar)-6-propyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-10,11-diol BDBM50007422 CHEMBL225230 Lopac0_000435 PDSP1_000852 SCHEMBL7997518 (R)-10,11-Dihydroxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolinium 6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol; hydrochloride BPBio1_001404 CTK4D8694 N-propylnorapomorphine-(+) PDSP2_000839 Win-28928 (-)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol (-)-N-Propylnorapomorphine 18426-20-5 AC1L50G2 CHEBI:92234 D07XYQ NH381P1BR8 r(-)-10,11-dihydroxy-N-n-propylnoraporphine (9R)-10-propyl-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(17),2,4,6,13,15-hexaene-3,4-diol BDBM50012994 CHEMBL538542 PDSP1_000853 SKF-76783 [ Show all ]
Inchi Key	BTGAJCKRXPNBFI-OAHLLOKOSA-N
Inchi ID	InChI=1S/C19H21NO2/c1-2-9-20-10-8-12-4-3-5-14-17(12)15(20)11-13-6-7-16(21)19(22)18(13)14/h3-7,15,21-22H,2,8-11H2,1H3/t15-/m1/s1
PubChem CID	167715
ChEMBL	CHEMBL225230
IUPHAR	969
BindingDB	50007422, 50012994
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	25.0 nM	PMID15588094	BindingDB
EC50	25.12 nM	PMID15588094	ChEMBL
IC50	1e-09 nM	PMID3156993	ChEMBL
IC50	1e-06 nM	PMID3156993	ChEMBL
Kd	20.0 nM	PMID8632409	BindingDB,ChEMBL
Ki	<10000.0 nM	PMID9021894	BindingDB
Ki	0.0741 nM	PMID24325578	BindingDB
Ki	0.075 nM	PMID24325578	BindingDB
Ki	0.11 nM	PMID24325578	BindingDB
Ki	0.38 nM	PMID24325578	BindingDB
Ki	1.25893 - 31.6228 nM	PMID8301582, PMID7756621	IUPHAR
Ki	1.6 nM	PMID24325578	BindingDB
Ki	1.7 nM	PMID24325578	BindingDB
Ki	4.9 nM	PMID24325578	BindingDB
Ki	11.0 nM	PMID24325578	BindingDB
Ki	50.0 nM	PMID9784114	BindingDB,ChEMBL
Ki	257.0 nM	PMID8097160	BindingDB
Ki	3200.0 nM	PMID9021894	BindingDB

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