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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL98665
Molecular formula	C43H47FN4O6S
IUPAC name	3-methylbutyl N-[2-[4-[[5-[3-(N-benzoylanilino)propanoyl]-4-ethyl-2-propylimidazol-1-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamate
Molecular weight	766.929
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	8.9
Synonyms	SCHEMBL242909 butyloxy 2-[2-(4-{4-ethyl-5-[3-diphenylcarboxamidopropanoyl]-2-propyl-1H-1-imidazolylmethyl}-3-fluorophenyl)phenylsulfonyl]caboxamido isopentyloxy 2-[2-(4-{4-ethyl-5-[3-biphenylcarboxamidopropanoyl]-2-propyl-1H-1-imidazolylmethyl}-3-fluorophenyl)phenylsulfonyl]caboxamido N-[3-[1-[[2'-[[(Isopentyloxycarbonyl)amino]sulfonyl]-3-fluoro-1,1'-biphenyl-4-yl]methyl]-4-ethyl-2-propyl-1H-imidazol-5-yl]-3-oxopropyl]-N-phenylbenzamide BDBM50032352
Inchi Key	ADYRAXCAXZNNFK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C43H47FN4O6S/c1-5-15-40-45-37(6-2)41(38(49)24-26-47(34-18-11-8-12-19-34)42(50)31-16-9-7-10-17-31)48(40)29-33-23-22-32(28-36(33)44)35-20-13-14-21-39(35)55(52,53)46-43(51)54-27-25-30(3)4/h7-14,16-23,28,30H,5-6,15,24-27,29H2,1-4H3,(H,46,51)
PubChem CID	10033116
ChEMBL	CHEMBL98665
IUPHAR	N/A
BindingDB	50032352
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.06 nM	PMID7636854	BindingDB
IC50	0.06 nM	PMID7636854	ChEMBL
IC50	0.18 nM	PMID7636854	BindingDB,ChEMBL

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