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GPCR

NameProbable G-protein coupled receptor 142
SpeciesHomo sapiens (Human)
GeneGPR142
SynonymKIF19
G-protein coupled receptor PGR2
GPR142
AXOR103
DiseaseN/A
Length462
Amino acid sequenceMSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProtQ7Z601
Protein Data BankN/A
GPCR-HGmod modelQ7Z601
3D structure modelThis predicted structure model is from GPCR-EXP Q7Z601.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2069161
IUPHAR132
DrugBankN/A

Ligand

NameCHEMBL2409010
Molecular formulaC21H23N7OS
IUPAC nameN-[(1-methylimidazol-4-yl)methyl]-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-5-propylpyrazole-4-carboxamide
Molecular weight421.523
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP2.3
SynonymsBDBM50437423
Inchi KeySVVOUQZKBGAKJS-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H23N7OS/c1-4-6-17-16(20(29)22-10-15-12-27(3)13-24-15)11-25-28(17)21-23-9-14(2)19(26-21)18-7-5-8-30-18/h5,7-9,11-13H,4,6,10H2,1-3H3,(H,22,29)
PubChem CID72165164
ChEMBLCHEMBL2409010
IUPHARN/A
BindingDB50437423
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5015000.0 nMPMID24900747BindingDB,ChEMBL

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