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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2069491
Molecular formula	C20H17N5O2
IUPAC name	(2S)-2-amino-3-(4-cyanophenyl)-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)propanamide
Molecular weight	359.389
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	0.5
Synonyms	BDBM50390586
Inchi Key	TUIACQQLTDHMAT-KRWDZBQOSA-N
Inchi ID	InChI=1S/C20H17N5O2/c21-11-14-3-1-13(2-4-14)9-17(22)19(26)25-18-10-16(12-24-20(18)27)15-5-7-23-8-6-15/h1-8,10,12,17H,9,22H2,(H,24,27)(H,25,26)/t17-/m0/s1
PubChem CID	70693006
ChEMBL	CHEMBL2069491
IUPHAR	N/A
BindingDB	50390586
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	4600.0 nM	PMID22884988	BindingDB,ChEMBL
Emax	79.0 %	PMID22884988	ChEMBL

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