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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

NameSR-02000000443
Molecular formulaC20H20ClN3O
IUPAC name4-(benzylamino)-5-chloro-2-(4-propan-2-ylphenyl)pyridazin-3-one
Molecular weight353.85
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP4.7
Synonyms4-(benzylamino)-5-chloro-2-(4-propan-2-ylphenyl)pyridazin-3-one
4-(benzylamino)-5-chloro-2-p-cumenyl-pyridazin-3-one
5-chloranyl-4-[(phenylmethyl)amino]-2-(4-propan-2-ylphenyl)pyridazin-3-one
5-chloro-4-[(phenylmethyl)amino]-2-(4-propan-2-ylphenyl)-3-pyridazinone
BDBM75914
[ Show all ]
Inchi KeyBUBKAZGCPPCWCH-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H20ClN3O/c1-14(2)16-8-10-17(11-9-16)24-20(25)19(18(21)13-23-24)22-12-15-6-4-3-5-7-15/h3-11,13-14,22H,12H2,1-2H3
PubChem CID46835807
ChEMBLCHEMBL1734822
IUPHARN/A
BindingDB75914
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5016200.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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