You can:
Name | Nociceptin receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprl1 |
Synonym | NOP receptor NOP-r NOPr OP4 Orphanin FQ receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 367 |
Amino acid sequence | MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA |
UniProt | P35370 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4503 |
IUPHAR | 320 |
DrugBank | N/A |
Name | CHEMBL170674 |
---|---|
Molecular formula | C28H45N3O |
IUPAC name | 8-cyclopentadecyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
Molecular weight | 439.688 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 7.9 |
Synonyms | BDBM50087696 8-Cyclopentadecyl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 1-Phenyl-8-(cyclopentadecane-1-yl)-1,3,8-triazaspiro[4.5]decane-4-one |
Inchi Key | TWCNPRKIXIASRN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H45N3O/c32-27-28(31(24-29-27)26-18-14-11-15-19-26)20-22-30(23-21-28)25-16-12-9-7-5-3-1-2-4-6-8-10-13-17-25/h11,14-15,18-19,25H,1-10,12-13,16-17,20-24H2,(H,29,32) |
PubChem CID | 44380305 |
ChEMBL | CHEMBL170674 |
IUPHAR | N/A |
BindingDB | 50087696 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 600.0 nM | PMID10782696 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218